Antimicrobial resistance in bacterial wound, skin, soft tissue and surgical site infections in Central, Eastern, Southern and Western Africa: A systematic review and meta-analysis

Antimicrobial resistance (AMR) is a significant global threat, particularly in Central, Eastern, Southern, and Western Africa. This systematic review reveals the prevalence of Staphylococcus aureus, Eschericheria coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii in clinically infected wounds, SSTI, and surgical site infections in these regions. AMR was high across all five species, with S. aureus being resistant to methicillin in over 40% of isolates, E. coli and K. pneumoniae resistant to amoxicillin-clavulanic acid in 80%, and P. aeruginosa and A. baumannii resistant to anti-pseudomonal carbapenems in 20%.